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The most traditional use the whole virus, either inactivated or attenuated such as polio and measles, respectively or fragments of it such as whooping cough. There are other slightly more novel methods, in which a harmless empty virus viral vector is used that carries either genes that express proteins or parts of proteins that belong to the virus against which it is intended to create immunity.
And other completely new methods such as those that incorporate encapsulation of the genetic material that contains the instructions for making virus-specific proteins. Both vaccines are quite similar since they both contain the information necessary to synthesize the main antigen of the coronavirus, which is the spike protein S , which is found on the surface of the virus. To put it in other words, this protein is like the key that the virus uses to enter the cells of our body.
Once one of these vaccines is administered, the mRNA enters the cells and serves as a template to generate copies of the S protein. After this process, the cell removes the mRNA. Meanwhile, the manufactured proteins are transported to the surface of the cell, or fragmented into small pieces that also appear on the surface, and in this way are recognized by the immune system, generating antibodies and memory cells.
In the case of being infected after the administration of a vaccine, the body recognizes the virus and fights it. The two vaccines require two doses to increase their effectiveness, although the time between the two inoculations is different.
Pfizer’s requires 21 days between doses and Moderna’s The main disadvantage of these vaccines is their transport and storage, as it requires a permanent cold chain with extremely low temperatures that require freezers of and degree centigrade. Scheme of the Coronavirus structure. The next vaccine to be approved in the European Union was from the pharmaceutical company AstraZeneca.
This vaccine uses an inactivated adenovirus, that is, a virus that cannot divide within our body, as a vector to introduce the genetic material necessary for our cells to generate the coronavirus spine protein and thus our immune system responds by creating antibodies.
Like the previous ones, this vaccine requires two doses to be more effective, and both must be between 10 and 12 weeks apart preferably This vaccine is transported and stored between 2 and 8 degrees Celsius, which facilitates its distribution compared to those mentioned above.
Another vaccine of the same type has recently been approved in the United States and Canada developed by the Belgian company Janssen, and it also uses a similar vector inactivated adenovirus and which, unlike AstraZeneca’s, requires a single dose.
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